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Application of γ‐Valerolactone as an Alternative Biomass‐Based Medium for Aminocarbonylation Reactions
Author(s) -
MarosvölgyiHaskó Diána,
Lengyel Blanka,
Tukacs József M.,
Kollár László,
Mika László T.
Publication year - 2016
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600389
Subject(s) - iodobenzene , chemistry , carbon monoxide , selectivity , catalysis , bar (unit) , substrate (aquarium) , carbonylation , homogeneous , organic chemistry , physics , oceanography , meteorology , geology , thermodynamics
γ‐Valerolactone (GVL) was proposed as a renewable, nontoxic reaction medium with negligible vapor pressure for homogeneous Pd‐catalyzed aminocarbonylation reactions. Iodobenzene as a model substrate and its 4‐substituted derivatives were converted to the corresponding 2‐ketocarboxamides with high conversions and chemoselectivities in γ‐valerolactone. The effect of carbon monoxide pressure and reaction temperature on the conversion and selectivities were studied in the range 1–50 bar and 25–100 °C, respectively. The highest conversion and selectivity was achieved at 25 bar and 50 °C for iodobenzene in GVL for 24 h.