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Glutathione Bioresponsive Cyclodextrin Nanosponges
Author(s) -
Trotta Francesco,
Caldera Fabrizio,
Dianzani Chiara,
Argenziano Monica,
Barrera Giuseppina,
Cavalli Roberta
Publication year - 2016
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600105
Subject(s) - cyclodextrin , glutathione , chemistry , combinatorial chemistry , biochemistry , enzyme
Invited for this month's cover is Prof. Francesco Trotta′s group from the University of Torino, Italy. The cover picture shows the chemical structure of a glutathione‐responsive β‐cyclodextrin nanosponge, bearing disulfide bridges and loaded with anticancer doxorubicin (red and white pills). Glutathione thiol groups are able to reduce the nanosponge disulfide moieties. The cleavage of the disulfide bridges allows a targeted release of anticancer drugs into glutathione‐rich chemoresistant tumor cells. Read the full text of the article at 10.1002/cplu.201500531.