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pH‐Dependent Cancer‐Directed Photodynamic Therapy by a Water‐Soluble Graphitic‐Phase Carbon Nitride–Porphyrin Nanoprobe
Author(s) -
Chan ChiFai,
Zhou Yan,
Guo Hongyu,
Zhang Junying,
Jiang Lijun,
Chen Wei,
Shiu KwokKeung,
Wong WaiKwok,
Wong KaLeung
Publication year - 2016
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600085
Subject(s) - graphitic carbon nitride , porphyrin , photosensitizer , photodynamic therapy , nanomaterials , chemistry , nanoprobe , solubility , conjugated system , photochemistry , nuclear chemistry , photocatalysis , materials science , catalysis , nanotechnology , nanoparticle , organic chemistry , polymer
Theranostic photodynamic nanomaterials suffer from poor water solubility and nontargeted toxicity. A water‐soluble graphitic‐phase carbon nitride‐based material (g‐C 3 N 4 ) conjugated to a positively charged porphyrin P2 (conjugating concentration: 60 μ m mg −1 mL −1 ) is shown to be a new concept of photodynamic therapeutic agent (g‐C 3 N 4 –P2). The pH‐sensitive emission of g‐C 3 N 4 is the driving force for the generation of 1 O 2 from g‐C 3 N 4 –P2. The amount of 1 O 2 /light generated from a photosensitizer porphyrin can be controlled by the pH‐sensitive emission of g‐C 3 N 4 at acidic pH (pH 4–6), especially under acidic conditions mimicking those of tumor tissue, and thus has the potential to be utilized as a cancer‐selective PDT agent.
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