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A pH‐Responsive Soluble‐Polymer‐Based Homogeneous Ruthenium Catalyst for Highly Efficient Asymmetric Transfer Hydrogenation (ATH)
Author(s) -
Xie Yinzheng,
Wang Mengpan,
Wu Xiaohui,
Chen Chen,
Ma Wenbo,
Dong Qifeng,
Yuan Mingming,
Hou Zhenshan
Publication year - 2016
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201600062
Subject(s) - chemistry , catalysis , ruthenium , aqueous solution , transfer hydrogenation , polymer , homogeneous , copolymer , acrylamide , polymer chemistry , organic chemistry , physics , thermodynamics
A pH‐responsive polymer has been synthesized successfully by means of copolymerization of dimethyl aminopropyl acrylamide (DMAPA) and N ‐ p ‐styrenesulfonyl‐1,2‐diphenylethylenediamine (V‐TsDPEN). The pH‐responsive polymer coordination ruthenium complex was thus prepared and employed as an efficient catalyst for the asymmetric transfer hydrogenation (ATH) of various ketones. The polymer catalyst exhibited an attractive pH‐induced phase‐separable behavior in water: it could be dissolved in water when the pH of the solution was lower than 6.5 at the beginning of the reaction, but was precipitated completely from water when the pH of the solution was above 8.5 after reaction. Additionally, the catalysts were highly efficient for the ATH of a wide range of substrates that bore different functional groups and could be recycled easily from the aqueous solution by means of self‐separation. They could be recycled eight times without significant changes in catalytic activity and enantioselectivity.