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Self‐Assembled Dendron–Cyclodextrin Nanotubes with a Polyethylenimine Surface and Their Gene Delivery Capability
Author(s) -
Lee Jeonghun,
Min Doohong,
Oh EunTaex,
Yoon Haerry,
Park Heon Joo,
Kim Chulhee
Publication year - 2016
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201500376
Subject(s) - polyethylenimine , dendrimer , chemistry , cyclodextrin , gene delivery , nanotube , polymer , surface modification , nanotechnology , transfection , polyelectrolyte , biophysics , carbon nanotube , polymer chemistry , organic chemistry , biochemistry , gene , materials science , biology
Self‐assembled dendron–cyclodextrin nanotubes (Den‐CD‐NTs) with selected surface functionalities can serve as templates for the formation of complexes with polymers, and the resulting nanotube–polymer complexes can be utilized as gene carriers. The negatively charged surfaces of Den‐CD‐NTs were covered with a positively charged polyethylenimine (PEI) layer using electrostatic interactions, and the resulting nanotube–PEI complex, having a positively charged surface exhibited intracellular uptake. Furthermore, the nanotube–PEI complex exhibited the capability for DNA complexation with reduced enzymatic degradation, and also showed higher transfection efficiency and lower cytotoxicity than PEI. Therefore, Den‐CD‐NTs, in simple complexation with a surface PEI layer, are potentially useful gene delivery vectors.