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Magnetic Dextran Nanoparticles That Bear Hydrophilic Porphyrin Derivatives: Bimodal Agents for Potential Application in Photodynamic Therapy
Author(s) -
Mbakidi JeanPierre,
Brégier Frédérique,
Ouk TanSothea,
Granet Robert,
Alves Sandra,
Rivière Eric,
Chevreux Sylviane,
Lemercier Gilles,
Sol Vincent
Publication year - 2015
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201500087
Subject(s) - hacat , porphyrin , photodynamic therapy , dextran , nanoparticle , magnetic nanoparticles , superparamagnetism , cationic polymerization , materials science , photochemistry , nanotechnology , chemistry , combinatorial chemistry , organic chemistry , polymer chemistry , in vitro , magnetization , biochemistry , physics , quantum mechanics , magnetic field
This study reports the chemical synthesis of a class of dextran superparamagnetic nanoparticles that bear hydrophilic porphyrin units covalently grafted by a click chemistry reaction in aqueous solution. Magnetic nanoparticles are used in magnetic resonance imaging (MRI) and hyperthermia, and the grafting of hydrophilic photosensitizers (PS) leads to elaborate new multifunctional platforms for potential diagnostic and targeted photodynamic therapy (PDT). The therapeutic potential for PDT of these nanoparticles is evaluated in vitro against the HaCaT cell line. The results show that these new multicharged nanomagnets—in particular, those that bear cationic porphyrins—show a significant uptake and an interesting photocytotoxic activity toward HaCaT cells. The whole series of these synthesized PS are massively incorporated inside HaCat cells and associated with mitochondria.

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