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Controlling Localization and Excretion of Nanoparticles by Click Modification of the Surface Chemical Structures inside Living Cells
Author(s) -
Ito Takeo,
Nakamura Takuma,
Kusaka Eriko,
Kurihara Ryohsuke,
Tanabe Kazuhito
Publication year - 2015
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201402436
Subject(s) - bioorthogonal chemistry , surface modification , click chemistry , excretion , membrane , nanoparticle , intracellular , nanotechnology , biophysics , chemistry , chemical modification , kinetics , materials science , combinatorial chemistry , biochemistry , biology , physics , quantum mechanics
Surface modification of silica nanoparticles (SiNPs) inside living cells was conducted by using the copper‐free bioorthogonal click reaction to evaluate the effects of surface chemical structures on dynamic behavior and excretion of SiNPs. The results demonstrated the spatial translocation of intracellular SiNPs to the plasma membrane upon surface modification in situ with phospholipids. Moreover, the extent and kinetics of excretion of the SiNPs from inside the cell were enhanced by modification.