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Chemically Modified Diatoms Biosilica for Bone Cell Growth with Combined Drug‐Delivery and Antioxidant Properties
Author(s) -
Cicco Stefania R.,
Vona Danilo,
De Giglio Elvira,
Cometa Stefania,
MattioliBelmonte Monica,
Palumbo Fabio,
Ragni Roberta,
Farinola Gianluca M.
Publication year - 2015
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201402398
Subject(s) - scavenger , antioxidant , chemistry , osteoblast , reactive oxygen species , drug delivery , antimicrobial , thalassiosira weissflogii , ciprofloxacin , drug , combinatorial chemistry , nitroxide mediated radical polymerization , pharmacology , biochemistry , organic chemistry , biology , radical polymerization , in vitro , antibiotics , polymer , phytoplankton , copolymer , nutrient
Nanostructured biosilica produced by Thalassiosira weissflogii diatoms is covalently functionalized with the cyclic nitroxide 2,6,6‐tetramethylpiperidine‐ N ‐oxyl (TEMPO), an efficient scavenger of reactive oxygen species (ROS) in biological systems. Drug delivery properties of the TEMPO‐functionalized biosilica are studied for Ciprofloxacin, an antimicrobial thoroughly employed in orthopedic or dental implant related infections. The resulting TEMPO‐biosilica, combining Ciprofloxacin drug delivery with anti‐oxidant properties, is demonstrated to be a suitable material for fibroblasts and osteoblast‐like cells growth.