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Halogenated Dodecaborate Clusters as Agents to Trigger Release of Liposomal Contents
Author(s) -
Awad Doaa,
Bartok Melinda,
Mostaghimi Farzin,
Schrader Imke,
Sudumbrekar Neeti,
Schaffran Tanja,
Jenne Carsten,
Eriksson Jonny,
Winterhalter Mathias,
Fritz Jürgen,
Edwards Katarina,
Gabel Detlef
Publication year - 2015
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201402286
Subject(s) - liposome , differential scanning calorimetry , phospholipid , transmission electron microscopy , chemistry , nanotechnology , atomic force microscopy , vesicle , biophysics , controlled release , chemical engineering , materials science , biochemistry , membrane , biology , physics , engineering , thermodynamics
Halogenated dodecaborates, and especially dodecaiodododecaborate(2−), are found to trigger effectively the release of the contents of phospholipid liposomes, including liposomes containing distearoylphosphatidylcholine and cholesterol, which are used clinically in cancer therapy. The basis of the release is studied through differential scanning calorimetry, cryo‐transmission electron microscopy, and atomic force microscopy. Upon administration at high concentrations, drastic morphological changes are induced by the dodecaborates. Their possible use in triggered release is suggested.