Premium
DNA Targeting by Cationic Porphyrin–Ruthenium(II) Conjugates
Author(s) -
Musetti Caterina,
Spagnul Cinzia,
Mion Giuliana,
Da Ros Sivia,
Gianferrara Teresa,
Sissi Claudia
Publication year - 2015
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201402275
Subject(s) - porphyrin , ruthenium , cationic polymerization , chemistry , dna , conjugate , macromolecule , combinatorial chemistry , adduct , stereochemistry , photodynamic therapy , photochemistry , biochemistry , organic chemistry , catalysis , mathematical analysis , mathematics
Porphyrins and metalloporphyrins are investigated extensively as potential anticancer drugs. They work as DNA binding agents as well as photosensitizers in photodynamic therapy. Conjugation of the macrocycle with organometallic complexes is a powerful tool to implement the water solubility of the adducts and to provide distinct cytotoxic properties. Herein, six fourfold‐symmetric cationic porphyrin–ruthenium(II) conjugates ( P1 – P6 ) are considered, which differ from one another by the substituents on the Ru II fragments, the linkage of the metal fragments to the porphyrin, and the total positive charge. Their interaction with DNA sequences arranged in different conformations is investigated. The data suggest that the tested conjugates discriminate poorly between different DNA structures. Indeed, unfolded DNA works efficiently as a template for the cationic conjugates. Nevertheless, they are extremely efficient in cleaving the macromolecule upon irradiation, regardless of its structural arrangement.