Metal–Organic Framework Co( D ‐Cam) 1/2 (bdc) 1/2 (tmdpy) for Improved Enantioseparations on a Chiral Cyclodextrin Stationary Phase in Gas Chromatography

Initial efforts to combine a chiral metal–organic framework (MOF), Co( D ‐Cam) 1/2 (bdc) 1/2 (tmdpy) ( D ‐Cam= D ‐camphoric acid, bdc=1,4‐benzenedicarboxylic acid, tmdpy=4,4′‐trimethylenedipyridine), with peramylated β‐cyclodextrins to investigate whether the use of a MOF can enhance enantioseparations on a cyclodextrin stationary phase are reported. Compared with columns of peramylated β‐cyclodextrin incorporated in a MOF containing sodium chloride, the column of peramylated β‐cyclodextrin+MOF shows excellent selectivity for the recognition of racemates, and higher resolutions are achieved on the peramylated β‐cyclodextrin+MOF stationary phase. Experimental results indicate that the use of Co( D ‐Cam) 1/2 (bdc) 1/2 (tmdpy) can improve enantioseparations on peramylated β‐cyclodextrins. This is the first report that chiral MOFs can improve enantioseparations on a chiral stationary phase for chromatography.