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Cover Picture: Assembly Dependent Fluorescence Enhancing Nucleic Acids in Sequence‐Specific Detection of Double‐Stranded DNA (ChemPlusChem 1/2014)
Author(s) -
Doluca Osman,
Hale Tracy K.,
Edwards Patrick J. B.,
González Carlos,
Filichev Vyacheslav V.
Publication year - 2014
Publication title -
chempluschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201300370
Subject(s) - oligonucleotide , dna , nucleic acid , fluorescence , sequence (biology) , pyrene , chemistry , dna sequencing , combinatorial chemistry , rna , g quadruplex , biophysics , computational biology , biochemistry , gene , biology , organic chemistry , physics , quantum mechanics
The cover picture shows a DNA strand forming a highly stable G‐quadruplex that can be converted into an efficient DNA triplex‐forming oligonucleotide by incorporating a pyrene intercalator into the sequence. Further modification by a thiazole orange derivative results in a highly fluorescent DNA triplex that is formed even in the presence of complementary RNA. These properties pave the way to visualise genes in a sequence specific manner via DNA triplex formation in live cells. Further details can be found in the Full Paper on page 58 by Vyacheslav V. Filichev, Carlos González and co‐workers.