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Fluorescent Nanodiamonds with Bioorthogonally Reactive Protein‐Resistant Polymeric Coatings
Author(s) -
Rehor Ivan,
Mackova Hana,
Filippov Sergey K.,
Kucka Jan,
Proks Vladimir,
Slegerova Jitka,
Turner Stuart,
Van Tendeloo Gustaaf,
Ledvina Miroslav,
Hruby Martin,
Cigler Petr
Publication year - 2014
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201300339
Subject(s) - nanotechnology , fluorescence , polymer , bioorthogonal chemistry , coating , biomolecule , click chemistry , protein adsorption , adsorption , colloid , materials science , chemistry , molecule , combinatorial chemistry , organic chemistry , quantum mechanics , physics
The novel synthesis of a polymeric interface grown from the surface of bright fluorescent nanodiamonds is reported. The polymer enables bioorthogonal attachment of various molecules by click chemistry; the particles are resistant to nonspecific protein adsorption and show outstanding colloidal stability in buffers and biological media. The coating fully preserves the unique optical properties of the nitrogen‐vacancy centers that are crucial for bioimaging and sensoric applications.