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Synthesis of Polyboronic Acid Functionalized Hierarchically Ordered Macro‐/Mesoporous Silica for Selective Enrichment of Glycopeptides for Mass Spectrometric Analysis
Author(s) -
Yan Yinghua,
Deng Chunhui,
Zheng Zhifang,
Zhang Xiangmin,
Yang Pengyuan
Publication year - 2014
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201300335
Subject(s) - glycopeptide , mesoporous material , selectivity , porosity , mesoporous silica , chemistry , combinatorial chemistry , materials science , chromatography , organic chemistry , catalysis , antibiotics , biochemistry
A novel hierarchically ordered macro/mesoporous silica was functionalized with polyboronic acid (HOMMS@PolyVPBA). This composite possesses the attractive features of high surface area and large accessible porosity, and was applied to enrich glycopeptides. Here the HOMMS material was introduced into glycoproteome for the first time. The HOMMS@PolyVPBA gave remarkable selectivity for glycopeptides even at a low molar ratio of glycopeptides/nonglycopeptides (1:50) with a very rapid enrichment speed (only 10 min) and low detection (1 ng μ L −1 ). Therefore the synthetic HOMMS@PolyVPBA might be a promising selective enrichment material for glycoproteome analysis.