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Azahelicene Superbases as MAILD Matrices for Acidic Analytes
Author(s) -
Napagoda Mayuri,
Rulíšek Lubomír,
Jančařík Andrej,
Klívar Jiří,
Šámal Michal,
Stará Irena G.,
Starý Ivo,
Šolínová Veronika,
Kašička Václav,
Svatoš Aleš
Publication year - 2013
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201300258
Subject(s) - helicene , chemistry , matrix (chemical analysis) , analyte , proton , matrix assisted laser desorption/ionization , desorption , mass spectrometry , ionization , analytical chemistry (journal) , combinatorial chemistry , adsorption , chromatography , organic chemistry , ion , molecule , physics , quantum mechanics
Fitting the profile : A superbasic 1,14‐diaza[5]helicene can serve as an efficient, ionless matrix for matrix‐assisted ionization/laser desorption (MAILD) spectrometry. The matrix outperforms other bases by acting as a kinetically active proton sponge and is highly suitable for high‐throughput metabolomics analysis. There is a correlation between the basicity (and proton‐sponge character) of matrices and their efficacy in MAILD‐MS.