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9‐Fluorenone‐2‐Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds
Author(s) -
Calogero Francesco,
Borrelli Stella,
Speciale Gaetano,
Christodoulou Michael S.,
Cartelli Daniele,
Ballinari Dario,
Sola Francesco,
Albanese Clara,
Ciavolella Antonella,
Passarella Daniele,
Cappelletti Graziella,
Pieraccini Stefano,
Sironi Maurizio
Publication year - 2013
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201300036
Subject(s) - fluorenone , carboxylic acid , chemistry , flow cytometry , fluorescence , fluorescence microscope , scaffold , biophysics , combinatorial chemistry , biochemistry , organic chemistry , biology , microbiology and biotechnology , fluorene , biomedical engineering , medicine , physics , quantum mechanics , polymer
The introduction of a hydrophobic group at position 7 of 9‐fluorenone‐2‐carboxylic acid generates new tubulin binders, the design of which is suggested by modeling studies. The synthesis is based on the use of 2,7‐dibromo‐fluorenone as starting material. The antiproliferative activity on two different cell lines, fluorescent microscopy, flow cytometry, and sedimentation assay tests confirmed the supposed mechanism.