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Biomimetic Mineralization of Calcium Phosphate on a Functionalized Porous Silicon Carbide Biomaterial
Author(s) -
Dey Archan,
van den Hoogen Chris. J.,
Rosso Michel,
Lousberg Niek,
Hendrix Marco M. R. M.,
Friedrich Heiner,
RamírezRico Joaquín,
Zuilhof Han,
de With Gijsbertus,
Sommerdijk Nico A. J. M.
Publication year - 2012
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201200118
Subject(s) - octacalcium phosphate , materials science , coating , chemical engineering , nucleation , monolayer , x ray photoelectron spectroscopy , biomineralization , scanning electron microscope , biomaterial , porosity , nanotechnology , calcium , chemistry , organic chemistry , composite material , metallurgy , engineering
Abstract Porous biomorphic silicon carbide ( bio SiC) is a structurally realistic, high‐strength, and biocompatible material which is promising for application in load‐bearing implants. The deposition of an osteoconductive coating is essential for further improvement of its integration with the surrounding tissue. A new strategy towards biomimetic calcium phosphate coatings on bio SiC is described. X‐ray photoelectron spectroscopy (XPS) analysis shows that using 10‐undecenoic acid methyl ester a covalently bound monolayer can be synthesized on the surface of the bio SiC. After hydrolysis it exposes carboxylic acid groups that promote the selective nucleation and growth of a very well‐defined crystalline layer of calcium phosphate. The resulting calcium phosphate coating is characterized by X‐ray diffraction and electron microscopy techniques. Further, ion beam imaging is employed to quantify the mineral deposition meanwhile, three‐dimensional dual‐beam imaging (FIB/SEM) is used to visualize the bio SiC/mineral interface. The monolayer is show to actively induce the nucleation of a well‐defined and highly crystalline mixed octacalcium phosphate/hydroxyapatite (OCP/HAP) coating on implantable bio SiC substrates with complex geometry. The mild biomimetic procedure, in principle, allows for the inclusion of bioactive compounds that aid in tissue regeneration. Moreover, the mixed OCP/HAP phase will have a higher solubility compared to HAP, which, in combination with its porous structure, is expected to render the coating more reabsorbable than standard HAP coatings.