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Pore Length Effect on Drug Uptake and Delivery by Mesoporous Silicas
Author(s) -
Burguete Pedro,
Beltrán Aurelio,
Guillem Carmen,
Latorre Julio,
PérezPla Francisco,
Beltrán Daniel,
Amorós Pedro
Publication year - 2012
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201200099
Subject(s) - mesoporous material , ibuprofen , chemistry , drug delivery , chemical engineering , porosity , mcm 41 , pulmonary surfactant , desorption , adsorption , nanoparticle , mesoporous silica , nanotechnology , chromatography , materials science , organic chemistry , pharmacology , medicine , biochemistry , engineering , catalysis
The capability of UVM‐7 silicas to work as supports for drug storage and delivery is investigated using ibuprofen as a model. UVM‐7 silicas are surfactant‐assisted synthesised mesoporous materials displaying a characteristic bimodal pore architecture related to their nanoparticulate texture. Strict control of the drug‐charge protocol allows the achievement of high ibuprofen loads, not only because of the availability of intra‐nanoparticle mesopores and large textural voids, but also owing to the decrease in pore‐blocking effects (with regard to related unimodal mesoporous materials such as MCM‐41) achieved through the shortening of the mesopore length. The UVM‐7/ibuprofen nanocomposites are characterised using XRD, TEM and N 2 adsorption/desorption isotherms, and the drug‐delivery processes are monitored by spectrometric techniques. The bimodal porosity results in two‐stage drug‐delivery processes, which are analysed through kinetic models.