Premium
[ 18 F]Si‐RiboRGD: From Design and Synthesis to the Imaging of α v β 3 Integrins in Melanoma Tumors
Author(s) -
Amigues Eric,
Schulz Jürgen,
SzlosekPinaud Magali,
Fernandez Philippe,
SilventePoirot Sandrine,
Brillouet Séverine,
Courbon Frédéric,
Fouquet Eric
Publication year - 2012
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201200022
Subject(s) - derivative (finance) , computer science , point (geometry) , positron emission tomography , visualization , content (measure theory) , protocol (science) , chemistry , nanotechnology , information retrieval , combinatorial chemistry , materials science , nuclear medicine , artificial intelligence , mathematics , medicine , geometry , financial economics , economics , mathematical analysis , alternative medicine , pathology
The winning combination : A new and promising 18 F‐labeled RGD derivative has been efficiently prepared by exploiting the advantages of “click” chemistry and a one‐step labeling protocol where a silicon‐based building blocks was used (see figure). This derivative could be a new starting point for improved visualization of α v β 3 ‐positive tumors by positron emission tomography.