[ 18 F]Si‐RiboRGD: From Design and Synthesis to the Imaging of α v β 3  Integrins in Melanoma Tumors | Zendy

Amigues Eric | Zendy; Schulz Jürgen | Zendy; SzlosekPinaud Magali | Zendy; Fernandez Philippe | Zendy; SilventePoirot Sandrine | Zendy; Brillouet Séverine | Zendy; Courbon Frédéric | Zendy; Fouquet Eric | Zendy

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[ 18 F]Si‐RiboRGD: From Design and Synthesis to the Imaging of α v β 3 Integrins in Melanoma Tumors

Author(s) -

Amigues Eric,

Schulz Jürgen,

SzlosekPinaud Magali,

Fernandez Philippe,

SilventePoirot Sandrine,

Brillouet Séverine,

Courbon Frédéric,

Fouquet Eric

Publication year - 2012

Publication title -

chempluschem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.801

H-Index - 61

ISSN - 2192-6506

DOI - 10.1002/cplu.201200022

Subject(s) - derivative (finance) , computer science , point (geometry) , positron emission tomography , visualization , content (measure theory) , protocol (science) , chemistry , nanotechnology , information retrieval , combinatorial chemistry , materials science , nuclear medicine , artificial intelligence , mathematics , medicine , geometry , financial economics , economics , mathematical analysis , alternative medicine , pathology

The winning combination : A new and promising 18 F‐labeled RGD derivative has been efficiently prepared by exploiting the advantages of “click” chemistry and a one‐step labeling protocol where a silicon‐based building blocks was used (see figure). This derivative could be a new starting point for improved visualization of α v β 3 ‐positive tumors by positron emission tomography.

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