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A Molecular Lock and Key: “Unlocked–Locked” Conformational Switching of a Receptor by Anions
Author(s) -
Dalapati Sasanka,
Alam Md. Akhtarul,
Jana Sankar,
Saha Rajat,
Biswas Saptarshi,
Guchhait Nikhil
Publication year - 2012
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201100036
Subject(s) - lock (firearm) , key (lock) , chemistry , receptor , conformational change , computer science , stereochemistry , engineering , biochemistry , computer security , mechanical engineering
Lock up your valuables : Receptor 1 acts as a “molecular lock” and anions act as “keys”; H 2 PO 4 − can “lock” 1 by switching it from its “unlocked” conformation, however, the structurally similar HSO 4 − cannot “lock” receptor 1 as evidenced by single‐crystal X‐ray analysis (see scheme). The “unlocked–locked” conformational switching of 1 was investigated by monitoring changes in fluorescence intensity in the presence of different anions.
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