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Application of Zeolitic Imidazolate Framework‐8 Nanoparticles for the Fluorescence‐Enhanced Detection of Nucleic Acids
Author(s) -
Liu Sen,
Wang Lei,
Tian Jingqi,
Luo Yonglan,
Chang Guohui,
Asiri Abdullah M.,
AlYoubi Abdulrahman O.,
Sun Xuping
Publication year - 2012
Publication title -
chempluschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.801
H-Index - 61
ISSN - 2192-6506
DOI - 10.1002/cplu.201100010
Subject(s) - imidazolate , nucleic acid , chemistry , nanoparticle , fluorescence , zeolitic imidazolate framework , dna , combinatorial chemistry , selectivity , nanotechnology , adsorption , biophysics , materials science , biochemistry , inorganic chemistry , organic chemistry , metal organic framework , biology , physics , quantum mechanics , catalysis
Stranded on a nanoparticle : For the first time, zeolitic imidazolate framework‐8 nanoparticles (ZIFNPs) have been used in an effective fluorescent sensing platform for nucleic acids. The DNA detection is accomplished in two steps: 1) ZIFNPs adsorb and quench the dye‐labeled single‐stranded DNA probe, and 2) subsequent hybridization of the probe with its target produces double‐stranded DNA, which detaches from the ZIFNP. The present system shows a high selectivity down to single‐base mismatch (see figure).