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Hyperpolarized 13 C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen‐induced Polarization: A Proof‐of‐Concept in vivo Study
Author(s) -
Stewart Neil J.,
Nakano Hitomi,
Sugai Shuto,
Tomohiro Mitsushi,
Kase Yuki,
Uchio Yoshiki,
Yamaguchi Toru,
Matsuo Yujirou,
Naganuma Tatsuya,
Takeda Norihiko,
Nishimura Ikuya,
Hirata Hiroshi,
Hashimoto Takuya,
Matsumoto Shingo
Publication year - 2021
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.202100338
Subject(s) - extracellular , nuclear magnetic resonance , in vivo , chemistry , magnetic resonance imaging , nuclear magnetic resonance spectroscopy , metabolism , biophysics , biochemistry , stereochemistry , medicine , biology , physics , microbiology and biotechnology , radiology
Abstract The front cover artwork is provided by the group of Dr. Neil J. Stewart, Prof. Hiroshi Hirata, and Dr. Shingo Matsumoto (Hokkaido University, Japan) as well as Dr. Takuya Hashimoto (Chiba University, Japan). The image shows hyperpolarized 13 C fumarate metabolism to hyperpolarized 13 C malate, which is released into the extracellular space in regions of necrotic cell death, where the cell membrane is disrupted. Read the full text of the Article at 10.1002/cphc.202001038.