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Chemical Processes Involving 18‐Crown‐6‐Ether in Activated Noncovalent Complexes with Protonated Peptides
Author(s) -
Abdelmouleh Marwa,
Lalande Mathieu,
Nicol Edith,
Frison Gilles,
Rest Guillaume,
Poully JeanChristophe
Publication year - 2021
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.202100075
Subject(s) - protonation , chemistry , electron transfer , crown ether , non covalent interactions , molecule , mass spectrometry , proton , computational chemistry , ether , chemical physics , photochemistry , organic chemistry , hydrogen bond , ion , physics , chromatography , quantum mechanics
These last decades, it has been widely assumed that 18‐crown‐6‐ether (CE) plays a spectator role during the chemical processes occurring in isolated host‐guest complexes between peptides or proteins and CE after activation in mass spectrometers. Our present experimental and theoretical results challenge this hypothesis by showing that CE can abstract a proton or a protonated molecule from protonated peptides after activation by collisions in argon or electron capture/transfer. Furthermore, thanks to comparison between experimental and calculated values of collision cross‐sections, we demonstrate that CE can change binding site after electron transfer. We also propose detailed mechanisms for these processes.