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Determination of Binding Strengths of Host‐Guest Complexes in Deep Eutectic Solvents Using Spin Probe Methodology
Author(s) -
Cantelli Andrea,
Franchi Paola,
Mezzina Elisabetta,
Lucarini Marco
Publication year - 2021
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.202001007
Subject(s) - electron paramagnetic resonance , chemistry , deep eutectic solvent , choline chloride , nitroxide mediated radical polymerization , spin probe , solvent , eutectic system , dissociation (chemistry) , solvation , thio , dissociation constant , inorganic chemistry , crystallography , organic chemistry , nuclear magnetic resonance , microstructure , physics , radical polymerization , copolymer , polymer , biochemistry , receptor
Electron paramagnetic resonance (EPR) and spin probe methodologies have been employed to study the complexation properties of cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) in the deep eutectic solvent (DES) choline chloride‐urea. In the presence of γ‐CD an affinity constant very similar to that measured in water was measured in DES with benzyl‐ tert‐ butyl nitroxide (BTBN). With β‐CD, complexation of BTBN is significantly depressed, although still maintained. Complexation of TEMPO radical probe by CB[7] or CB[8] was instead almost entirely cancelled in DES. In addition, this methodology enabled for the first time to measure the single rate constants for the association and dissociation processes with CDs in DES.