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Release of Warfarin from Human Serum Albumin by Water‐soluble CdSe Nanotetrapods
Author(s) -
Banerjee Sucheta,
Kistwal Tanuja,
Sajeevan Amritha,
Datta Anindya
Publication year - 2020
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.202000292
Subject(s) - warfarin , albumin , chemistry , human serum albumin , nanotechnology , chromatography , materials science , biochemistry , medicine , atrial fibrillation
Water soluble CdSe nanotetrapods are prepared by ligand exchange from organic‐soluble ones. In order to achieve this, oleic acid, which is the capping agent for as prepared water‐insoluble nanotetrapods, is exchanged with mercaptopropanoic acid (MPA). Shape and size of nanotetrapods are conserved upon ligand exchange. Ground state bleach recovery dynamics remain the same as well. However, they are completely non‐emissive. These water‐soluble nanotetrapods disrupt the secondary structure of Human Serum Albumin (HSA) and consequently, release warfarin bound to the protein.