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Cover Feature: In Silico Evidence That Protein Unfolding is a Precursor of Protein Aggregation (ChemPhysChem 5/2020)
Author(s) -
Bianco Valentino,
Franzese Giancarlo,
Coluzza Ivan
Publication year - 2020
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.202000092
Subject(s) - cover (algebra) , in silico , chemistry , feature (linguistics) , surface protein , protein aggregation , protein structure , aqueous solution , protein folding , biophysics , crystallography , biochemistry , biology , mechanical engineering , linguistics , philosophy , virology , engineering , gene
The Cover Feature illustrates partial unfolding of the native conformation and ultimately complete loss of the folded structures and formation of protein aggregates resulting from increasing the protein concentration in an aqueous environment. The water mediates the partial unfolding with no direct protein‐protein interactions. More information can be found in the Article by V. Bianco et al. on page 377 in Issue 5, 2020 (DOI: 10.1002/cphc.201900904).