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Lifetime of Para hydrogen in Aqueous Solutions and Human Blood
Author(s) -
Schmidt Andreas B.,
Wörner Jakob,
Pravdivtsev Andrey,
Knecht Stephan,
Scherer Harald,
Weber Stefan,
Hennig Jürgen,
Elverfeldt Dominik,
Hövener JanBernd
Publication year - 2019
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201900670
Subject(s) - aqueous solution , chemistry , rhodium , hydrogen , relaxation (psychology) , methanol , spin isomers of hydrogen , catalysis , analytical chemistry (journal) , computational chemistry , chemical physics , organic chemistry , psychology , social psychology
Abstract Molecular hydrogen has unique nuclear spin properties. Its nuclear spin isomer, para hydrogen ( p H 2 ), was instrumental in the early days of quantum mechanics and allows to boost the NMR signal by several orders of magnitude. p H 2‐ induced polarization (PHIP) is based on the survival of p H 2 spin order in solution, yet its lifetime has not been investigated in aqueous or biological media required for in vivo applications. Herein, we report longitudinal relaxation times ( T 1 ) and lifetimes of p H 2 ( τ P O C ) in methanol and water, with or without O 2 , NaCl, rhodium‐catalyst or human blood. Furthermore, we present a relaxation model that uses T 1 and τ P O Cfor more precise theoretical predictions of the H 2 spin state in PHIP experiments. All measured T 1 values were in the range of 1.4–2 s and τ P O Cvalues were of the order of 10–300 minutes. These relatively long lifetimes hold great promise for emerging in vivo implementations and applications of PHIP.