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Cu 2+ Effects on Beta‐Amyloid Oligomerisation Monitored by the Fluorescence of Intrinsic Tyrosine
Author(s) -
Alghamdi Abeer,
Wellbrock Thorben,
Birch David J. S.,
Vyshemirsky Vladislav,
Rolinski Olaf J.
Publication year - 2019
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201900565
Subject(s) - fluorescence , chemistry , peptide , copper , amyloid beta , biophysics , amyloid (mycology) , tyrosine , beta (programming language) , biochemistry , biology , inorganic chemistry , physics , organic chemistry , quantum mechanics , computer science , programming language
A non‐invasive intrinsic fluorescence sensing of the early stages of Alzheimer's beta amyloid peptide aggregation in the presence of copper ions is reported. By using time‐resolved fluorescence techniques the formation of beta amyloid‐copper complexes and the accelerated peptide aggregation are demonstrated. The shifts in the emission spectral peaks indicate that the peptides exhibit different aggregation pathways than in the absence of copper.