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Cover Feature: A Thermodynamic Model of Auto‐regulated Protein Assembly by a Supramolecular Scaffold (ChemPhysChem 8/2019)
Author(s) -
Rennie Martin L.,
Crowley Peter B.
Publication year - 2019
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201900325
Subject(s) - isothermal titration calorimetry , tetramer , supramolecular chemistry , chemistry , monomer , cover (algebra) , ligand (biochemistry) , cationic polymerization , feature (linguistics) , supramolecular assembly , crystallography , biochemistry , polymer chemistry , crystal structure , organic chemistry , polymer , mechanical engineering , linguistics , receptor , philosophy , engineering , enzyme
The Cover Feature illustrates auto‐regulated protein assembly in which a supramolecular ligand prompts tetramer formation and subsequent disassembly to a ligand‐coated monomer. Highly atypical isothermal titration calorimetry thermograms were obtained for the interactions of anionic sulfonato‐calix[8]arene and cationic cytochrome c. A modelling approach with Bayesian fitting provides new tools to understand such intricate assembly processes. More information can be found in the Article by M. L. Rennie and P. B. Crowley on page 1011 in Issue 8, 2019 (DOI: 10.1002/cphc.201900153).