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Highly Resolved Pure‐Shift Spectra on a Compact NMR Spectrometer
Author(s) -
CastaingCordier Thomas,
Bouillaud Dylan,
Bowyer Paul,
Gonçalves Olivier,
Giraudeau Patrick,
Farjon Jonathan
Publication year - 2019
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201801116
Subject(s) - spectrometer , pulse sequence , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , resolution (logic) , proton nmr , nmr spectra database , materials science , chemistry , spectral line , nuclear magnetic resonance , physics , computer science , optics , chromatography , astronomy , artificial intelligence
Benchtop NMR spectrometers experience a great success for a wide range of applications. However, their performance is highly limited by peak overlaps. Emerging “pure‐shift NMR” (PS NMR) methods have been intensively used at high field to enhance the resolution by homodecoupling strategies. Here, different PS methods have been implemented on a compact NMR spectrometer operating at 43 MHz. Among the PS methods, the recent PSYCHE scheme appears more sensitive than Zangger‐Sterk (ZS) experiments and offers a substantial resolution improvement as compared to 1D 1 H. On the other hand, despite their slightly lower sensitivity, ZS methods are more efficient to reduce broad signals and are more immune to strong couplings. Finally, the classical J‐resolved pulse sequence is more efficient to reduce larger signals for bigger‐sized molecules. The three approaches appear relevant for benchtop NMR and their combination forms an efficient toolbox to analyze a great diversity of samples.