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High Exchange Rate Complexes of 129 Xe with Water‐Soluble Pillar[5]arenes for Adjustable Magnetization Transfer MRI
Author(s) -
Schnurr Matthias,
Joseph Roymon,
NaugolnyKeisar Alissa,
KaizermanKane Dana,
Bogdanoff Nils,
Schuenke Patrick,
Cohen Yoram,
Schröder Leif
Publication year - 2019
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201800618
Subject(s) - chemistry , magnetization transfer , saturation (graph theory) , counterion , magnetization , ion , molecule , chemical physics , xenon , analytical chemistry (journal) , nuclear magnetic resonance , magnetic field , organic chemistry , magnetic resonance imaging , medicine , physics , mathematics , combinatorics , quantum mechanics , radiology
Macrocyclic host structures for generating transiently bound 129 Xe have been used in various ultra‐sensitive NMR and MRI applications for molecular sensing of biochemical analytes. They are based on hyperpolarized nuclei chemical exchange saturation transfer (Hyper‐CEST). Here, we tested a set of water‐soluble pillar[5]arenes with different counterions in order to compare their potential contrast agent abilities with that of cryptophane‐A (CrA), the most widely used host for such purposes. The exchange of Xe with such compounds was found to be sensitive to the type of ions present in solution and can be used for switchable magnetization transfer (MT) contrast that arises from off‐resonant pre‐saturation. We demonstrate that the adjustable MT magnitude depends on the interplay of saturation parameters and found that the optimum MT contrast surpasses the CrA CEST performance at moderate saturation power. Since modification of such water‐soluble pillar[5]arenes is straightforward, these compounds can be considered a promising platform for designing various sensors that may complement the field of Xe HyperCEST‐based biosensing MRI.