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Distance‐independent Cross‐correlated Relaxation and Isotropic Chemical Shift Modulation in Protein Dynamics Studies
Author(s) -
Vögeli Beat,
Vugmeyster Liliya
Publication year - 2019
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201800602
Subject(s) - protein dynamics , relaxation (psychology) , chemical physics , dynamics (music) , chemistry , quantum , isotropy , modulation (music) , anisotropy , dipole , molecular dynamics , statistical physics , physics , computational chemistry , quantum mechanics , psychology , social psychology , acoustics
Cross‐correlated relaxation (CCR) in multiple‐quantum coherences differs from other relaxation phenomena in its theoretical ability to be mediated across an infinite distance. The two interfering relaxation mechanisms may be dipolar interactions, chemical shift anisotropies, chemical shift modulations or quadrupolar interactions. These properties make multiple‐quantum CCR an attractive probe for structure and dynamics of biomacromolecules not accessible from other measurements. Here, we review the use of multiple‐quantum CCR measurements in dynamics studies of proteins. We compile a list of all experiments proposed for CCR rate measurements, provide an overview of the theory with a focus on protein dynamics, and present applications to various protein systems.