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Front Cover: Improved Free‐Energy Landscape Quantification Illustrated with a Computationally Designed Protein–Ligand Interaction (ChemPhysChem 1/2018)
Author(s) -
Van Patten William J.,
Walder Robert,
Adhikari Ayush,
Okoniewski Stephen R.,
Ravichandran Rashmi,
Tinberg Christine E.,
Baker David,
Perkins Thomas T.
Publication year - 2018
Publication title -
chemphyschem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201701341
Subject(s) - front cover , energy landscape , cover (algebra) , atomic force microscopy , ligand (biochemistry) , energy (signal processing) , computer science , force spectroscopy , chemistry , nanotechnology , front (military) , biological system , chemical physics , computational chemistry , physics , biophysics , materials science , engineering , biology , biochemistry , quantum mechanics , mechanical engineering , receptor , meteorology
The Front Cover visualizes the concept of using single‐molecule force spectroscopy based on atomic force microscopy to better quantify the energy landscape underlying protein–ligand interactions. We introduce an enhanced AFM assay and apply it to probe the binding of a computationally designed protein to its target ligand. More information can be found in the Communication by W. J. Van Patten et al. on page 19 in Issue 1, 2018 (DOI: 10.1002/cphc.201701147).