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Enabling Fast Pseudo‐2D NMR Spectral Acquisition for Broadband Homonuclear Decoupling: The EXACT NMR Approach
Author(s) -
Ndukwe Ikenna E.,
Shchukina Alexandra,
Zorin Vadim,
Cobas Carlos,
Kazimierczuk Krzysztof,
Butts Craig P.
Publication year - 2017
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201700474
Subject(s) - homonuclear molecule , nuclear magnetic resonance spectroscopy , decoupling (probability) , spectroscopy , data acquisition , chemistry , transverse relaxation optimized spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , spectral line , signal (programming language) , computational physics , nuclear magnetic resonance , sampling (signal processing) , analytical chemistry (journal) , physics , molecule , optics , computer science , fluorine 19 nmr , organic chemistry , quantum mechanics , control engineering , astronomy , chromatography , detector , engineering , programming language , operating system
Pseudo‐2D NMR spectroscopy provides a means of acquiring broadband homonuclear decoupled spectra useful for structural characterization of complex molecules. However, data points concatenated in the direct dimension in these experiments are acquired over incremented time periods—leading to long acquisition times with no sensitivity benefits due to the absence of signal averaging between scans. Herein, the concept of EXACT NMR spectroscopy (“burst” non‐uniform sampling of data points) is explored in pseudo‐2D experiments with results revealing little or no loss in spectral quality or signal intensity despite the acceleration of acquisition—up to 400 % in some cases.