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Self‐Assembling Molecular Logic Gates Based on DNA Crossover Tiles
Author(s) -
Campbell Eleanor A.,
Peterson Evan,
Kolpashchikov Dmitry M.
Publication year - 2017
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201700109
Subject(s) - crossover , logic gate , dna computing , signal (programming language) , dna , computer science , nanotechnology , algorithm , materials science , biology , genetics , artificial intelligence , programming language
DNA‐based computational hardware has attracted ever‐growing attention due to its potential to be useful in the analysis of complex mixtures of biological markers. Here we report the design of self‐assembling logic gates that recognize DNA inputs and assemble into crossover tiles when the output signal is high; the crossover structures disassemble to form separate DNA stands when the output is low. The output signal can be conveniently detected by fluorescence using a molecular beacon probe as a reporter. AND, NOT, and OR logic gates were designed. We demonstrate that the gates can connect to each other to produce other logic functions.