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Tyramine Hydrochloride Based Label‐Free System for Operating Various DNA Logic Gates and a DNA Caliper for Base Number Measurements
Author(s) -
Fan Daoqing,
Zhu Xiaoqing,
Dong Shaojun,
Wang Erkang
Publication year - 2017
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201601291
Subject(s) - calipers , dna , base (topology) , chemistry , materials science , mathematics , biochemistry , geometry , mathematical analysis
DNA is believed to be a promising candidate for molecular logic computation, and the fluorogenic/colorimetric substrates of G‐quadruplex DNAzyme (G4zyme) are broadly used as label‐free output reporters of DNA logic circuits. Herein, for the first time, tyramine‐HCl (a fluorogenic substrate of G4zyme) is applied to DNA logic computation and a series of label‐free DNA‐input logic gates, including elementary AND, OR, and INHIBIT logic gates, as well as a two to one encoder, are constructed. Furthermore, a DNA caliper that can measure the base number of target DNA as low as three bases is also fabricated. This DNA caliper can also perform concatenated AND–AND logic computation to fulfil the requirements of sophisticated logic computing.