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Covalent and Non‐Covalent DNA–Gold‐Nanoparticle Interactions: New Avenues of Research
Author(s) -
Carnerero Jose M.,
JimenezRuiz Aila,
Castillo Paula M.,
PradoGotor Rafael
Publication year - 2017
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201601077
Subject(s) - nanoparticle , nanomedicine , biomolecule , colloidal gold , covalent bond , nanotechnology , dna , ligand (biochemistry) , oligonucleotide , polymer , chemistry , biocompatibility , dna origami , base pair , materials science , nanostructure , organic chemistry , biochemistry , receptor
The interactions of DNA, whether long, hundred base pair chains or short‐chained oligonucleotides, with ligands play a key role in the field of structural biology. Its biological activity not only depends on the thermodynamic properties of DNA–ligand complexes, but can and often is conditioned by the formation kinetics of those complexes. On the other hand, gold nanoparticles have long been known to present excellent biocompatibility with biomolecules and are themselves remarkable for their structural, electronic, magnetic, optical and catalytic properties, radically different from those of their counterpart bulk materials, and which make them an important asset in multiple applications. Therefore, thermodynamic and kinetic studies of the interactions of DNA with nanoparticles acting as small ligands are key for a better understanding of those interactions to allow for their control and modulation and for the opening of new venues of research in nanomedicine, analytic and biologic fields. The interactions of gold nanoparticles with both DNA polymers and their smaller subunits; special focus is placed on those interactions taking place with nonfunctionalized gold nanoparticles are reviewed in the present work.