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Inverted Micelle‐in‐Micelle Configuration in Cationic/Carbohydrate Surfactant Mixtures
Author(s) -
Das Saikat,
Xu Wenjin,
Lehmler HansJoachim,
Miller AnneFrances,
Knutson Barbara L.,
Rankin Stephen E.
Publication year - 2017
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201600908
Subject(s) - micelle , chemistry , cationic polymerization , pulmonary surfactant , nuclear overhauser effect , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , carbohydrate , crystallography , spectroscopy , organic chemistry , stereochemistry , aqueous solution , biochemistry , physics , quantum mechanics
Nuclear magnetic resonance is applied to investigate the relative positions and interactions between cationic and non‐ionic carbohydrate‐based surfactants in mixed micelles with D 2 O as the solvent. This is accomplished by using relaxation measurements [spin‐lattice ( T 1 ) and spin‐spin ( T 2 ) analysis] and nuclear Overhauser effect spectroscopy (NOESY). This study focuses on the interactions of n‐octyl β‐ d ‐glucopyranoside (C8G1) and β‐ d ‐xylopyranoside (C8X1) with the cationic surfactant hexadecyltrimethylammonium bromide (C 16 TAB). Whereas the interactions between carbohydrate and cationic surfactants are thermodynamically favorable, the NOESY results suggest that both of the sugar head groups are located preferentially at the interior core of the mixed micelles, so that they are not directly exposed to the bulk solution. The more hydrophilic sugar headgroups of C8G1 have more mobility than sugar heads of C8X1 owing to increased hydration. Herein, an inverted carbohydrate configuration in mixed micelles is proposed for the first time and supported by fluorescence spectroscopy experiments. This inverted carbohydrate headgroup configuration would limit the use of these mixed surfactants when access to the carbohydrate headgroup is important, but may present new opportunities where the carbohydrate‐rich core of the micelles can be exploited.