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Non‐Uniform‐Sampling Ultrahigh Resolution TOCSY NMR: Analysis of Complex Mixtures at Microgram Levels
Author(s) -
Kakita Veera M. R.,
Hosur Ramakrishna V.
Publication year - 2016
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201600255
Subject(s) - homonuclear molecule , resolution (logic) , analytical chemistry (journal) , chemistry , spectral line , sampling (signal processing) , covariance , range (aeronautics) , nuclear magnetic resonance , materials science , mathematics , physics , chromatography , molecule , statistics , optics , organic chemistry , astronomy , artificial intelligence , detector , computer science , composite material
Non‐uniform sampling in combination with homonuclear broadband decoupling along an indirect dimension, and indirect covariance processing are used to record ultrahigh resolution two‐dimensional TOCSY spectra in less than half an hour, for typical sample concentrations in the m m range. TOCSY correlations belonging to protons separated by as little as ≈2 Hz can be distinctly discerned. The utility of the technique for low concentrations has been demonstrated.