Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers | Zendy

Otarola Jessica | Zendy; Garrido Mariano | Zendy; Correa N. Mariano | Zendy; Molina Patricia G. | Zendy

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Square Wave Voltammetry: An Alternative Technique to Determinate Piroxicam Release Profiles from Nanostructured Lipid Carriers

Author(s) -

Otarola Jessica,

Garrido Mariano,

Correa N. Mariano,

Molina Patricia G.

Publication year - 2016

Publication title -

chemphyschem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.016

H-Index - 140

eISSN - 1439-7641

pISSN - 1439-4235

DOI - 10.1002/cphc.201600226

Subject(s) - piroxicam , voltammetry , cyclic voltammetry , square wave , chemistry , nanotechnology , square (algebra) , materials science , chemical engineering , electrochemistry , electrode , physics , mathematics , medicine , alternative medicine , pathology , voltage , quantum mechanics , geometry , engineering

A new, simple, and fast electrochemical (EC) method has been developed to determine the release profile of piroxicam, a nonsteroidal anti‐inflammatory drug, loaded in a drug delivery system based on nanostructured lipid carriers (NLCs). For the first time, the samples were analyzed by using square wave voltammetry, a sensitive EC technique. The piroxicam EC responses allow us to propose a model that explains the experimental results and to subsequently determine the amount of drug loaded into the NLCs formulation as a function of time. In vitro drug release studies showed prolonged drug release (up to 5 days), releasing 60 % of the incorporated drug. The proposed method is a promising and stable alternative for the study of different drug delivery systems.

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