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An Enzyme‐Based Half‐Adder and Half‐Subtractor with a Modular Design
Author(s) -
Fratto Brian E.,
Lewer Jessica M.,
Katz Evgeny
Publication year - 2016
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201600173
Subject(s) - subtractor , adder , modular design , chemistry , nanotechnology , computer science , stereochemistry , materials science , combinatorial chemistry , optoelectronics , programming language , cmos
A half‐adder and a half‐subtractor have been realized using enzymatic reaction cascades performed in a flow cell device. The individual cells were modified with different enzymes and assembled in complex networks to perform logic operations and arithmetic functions. The modular design of the logic devices allowed for easy re‐configuration, enabling them to perform various functions. The final output signals, represented by redox species [Fe(CN) 6 ] 3−/4− or NADH/NAD + , were analyzed optically to derive the calculation results. These output signals might be applicable in the future for actuation processes, for example, substance release activated by logically processed signals.