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Excited‐State Dynamics of a Two‐Photon‐Activatable Ruthenium Prodrug
Author(s) -
Greenough Simon E.,
Horbury Michael D.,
Smith Nichola A.,
Sadler Peter J.,
Paterson Martin J.,
Stavros Vasilios G.
Publication year - 2016
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201501075
Subject(s) - ruthenium , prodrug , ultrafast laser spectroscopy , chemistry , photochemistry , absorption (acoustics) , excited state , absorption spectroscopy , density functional theory , two photon absorption , spectroscopy , photodissociation , photodynamic therapy , catalysis , materials science , computational chemistry , organic chemistry , laser , biochemistry , physics , quantum mechanics , nuclear physics , optics , composite material
We present a new approach to investigate how the photodynamics of an octahedral ruthenium(II) complex activated through two‐photon absorption (TPA) differ from the equivalent complex activated through one‐photon absorption (OPA). We photoactivated a Ru II polypyridyl complex containing bioactive monodentate ligands in the photodynamic therapy window (620–1000 nm) by using TPA and used transient UV/Vis absorption spectroscopy to elucidate its reaction pathways. Density functional calculations allowed us to identify the nature of the initially populated states and kinetic analysis recovers a photoactivation lifetime of approximately 100 ps. The dynamics displayed following TPA or OPA are identical, showing that TPA prodrug design may use knowledge gathered from the more numerous and easily conducted OPA studies.