Premium
Enantiomeric Excess Sensitivity to Below One Percent by Using Femtosecond Photoelectron Circular Dichroism
Author(s) -
Kastner Alexander,
Lux Christian,
Ring Tom,
Züllighoven Stefanie,
Sarpe Cristian,
Senftleben Arne,
Baumert Thomas
Publication year - 2016
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201501067
Subject(s) - femtosecond , enantiopure drug , circular dichroism , enantiomer , chemistry , analytical chemistry (journal) , ionization , laser , enantiomeric excess , linear dichroism , detection limit , vibrational circular dichroism , x ray photoelectron spectroscopy , crystallography , optics , nuclear magnetic resonance , stereochemistry , chromatography , enantioselective synthesis , physics , organic chemistry , ion , catalysis
Photoelectron circular dichroism (PECD) is experimentally investigated with chiral specimens with varying amounts of enantiomeric excess ( ee ). As a prototype, we measure and analyze the photoelectron angular distribution from randomly oriented fenchone molecules in the gas phase that result from ionization with circularly polarized femtosecond laser pulses. The quantification of these measurements shows a linear dependence with respect to the ee values. In addition, differences in the ee values (denoted as detection limit) of below one percent can be distinguished for nearly enantiopure samples, as well as for almost racemates. In combination with the use of a reference, the assignment of absolute ee values is possible. The present measurement time is a few minutes, but this could be reduced. This table‐top laser‐based approach should facilitate widespread implementation in chiral analysis.