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Optimization of a Planar All‐Polymer Transistor for Characterization of Barrier Tissue
Author(s) -
Ramuz Marc,
Margita Kaleigh,
Hama Adel,
Leleux Pierre,
Rivnay Jonathan,
Bazin Ingrid,
Owens Róisín M.
Publication year - 2015
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201402878
Subject(s) - materials science , conductive polymer , nanotechnology , transistor , biocompatibility , planar , biointerface , pedot:pss , bioelectronics , electrode , optoelectronics , biosensor , polymer , chemistry , computer science , electrical engineering , composite material , computer graphics (images) , layer (electronics) , voltage , metallurgy , engineering
Abstract The organic electrochemical transistor (OECT) is a unique device that shows great promise for sensing in biomedical applications such as monitoring of the integrity of epithelial tissue. It is a label‐free sensor that is amenable to low‐cost production by roll‐to‐roll or other printing technologies. Herein, the optimization of a planar OECT for the characterization of barrier tissue is presented. Evaluation of surface coating, gate biocompatibility and performance, and optimization of the geometry of the transistor are highlighted. The conducting polymer poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate), which is used as the active material in the transistor, has the added advantage of allowing significant light transmission compared to traditional electrode materials and thus permits high‐quality optical microscopy. The combination of optical and electronic monitoring of cells shown herein provides the opportunity to couple two very complementary techniques to yield a low‐cost method for in vitro cell sensing.