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J ‐Edited Pure Shift NMR for the Facile Measurement of n J HH for Specific Protons
Author(s) -
Chaudhari Sachin Rama,
Suryaprakash N.
Publication year - 2015
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201402792
Subject(s) - homonuclear molecule , proton , chemistry , nuclear magnetic resonance spectroscopy , spectral line , spectroscopy , chemical shift , scalar (mathematics) , two dimensional nuclear magnetic resonance spectroscopy , proton nmr , nuclear magnetic resonance , analytical chemistry (journal) , physics , stereochemistry , molecule , nuclear physics , mathematics , organic chemistry , chromatography , quantum mechanics , astronomy , geometry
We report a novel 1D J ‐edited pure shift NMR experiment ( J ‐PSHIFT) that was constructed from a pseudo 2D experiment for the direct measurement of proton–proton scalar couplings. The experiment gives homonuclear broad‐band 1 H‐decoupled 1 H NMR spectra, which provide a single peak for chemically distinct protons, and only retain the homonuclear‐scalar‐coupled doublet pattern at the chemical‐shift positions of the protons in the coupled network of a specific proton. This permits the direct and unambiguous measurement of the magnitudes of the couplings. The incorporation of a 1D selective correlation spectroscopy (COSY)/ total correlation spectroscopy (TOCSY) block in lieu of the initial selective pulse, results in the exclusive detection of the correlated spectrum of a specific proton.