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Concluding the Amyloid Formation Pathway of a Coiled‐Coil‐Based Peptide from the Size of the Critical Nucleus
Author(s) -
Gerling Ulla I. M.,
Miettinen Markus S.,
Koksch Beate
Publication year - 2015
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201402400
Subject(s) - nucleus , amyloid (mycology) , peptide , chemistry , biophysics , coiled coil , p3 peptide , amyloid precursor protein , microbiology and biotechnology , biochemistry , biology , alzheimer's disease , medicine , pathology , inorganic chemistry , disease
The size of the critical nucleus acting as intermediate in the amyloid formation of a model peptide is calculated. The theoretical approach is based on experimentally determined amyloid formation rates and gives new insights into the amyloid formation pathway.