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Designing Fractal Nanostructured Biointerfaces for Biomedical Applications
Author(s) -
Zhang Pengchao,
Wang Shutao
Publication year - 2014
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201301230
Subject(s) - microscale chemistry , fractal , nanotechnology , biomolecule , biointerface , nanostructure , materials science , nanoscopic scale , chemistry , mathematics , mathematical analysis , mathematics education
Fractal structures in nature offer a unique “fractal contact mode” that guarantees the efficient working of an organism with an optimized style. Fractal nanostructured biointerfaces have shown great potential for the ultrasensitive detection of disease‐relevant biomarkers from small biomolecules on the nanoscale to cancer cells on the microscale. This review will present the advantages of fractal nanostructures, the basic concept of designing fractal nanostructured biointerfaces, and their biomedical applications for the ultrasensitive detection of various disease‐relevant biomarkers, such microRNA, cancer antigen 125, and breast cancer cells, from unpurified cell lysates and the blood of patients.