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Enantiodifferentiation through Frequency‐Selective Pure‐Shift 1 H Nuclear Magnetic Resonance Spectroscopy
Author(s) -
Castañar Laura,
PérezTrujillo Míriam,
Nolis Pau,
Monteagudo Eva,
Virgili Albert,
Parella Teodor
Publication year - 2014
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201301130
Subject(s) - nuclear magnetic resonance spectroscopy , coupling constant , chemistry , multiplet , spectroscopy , nuclear magnetic resonance , resonance (particle physics) , dispersion (optics) , chemical shift , two dimensional nuclear magnetic resonance spectroscopy , analytical chemistry (journal) , atomic physics , spectral line , stereochemistry , physics , organic chemistry , optics , particle physics , quantum mechanics , astronomy
A frequency‐selective 1D 1 H nuclear magnetic resonance (NMR) experiment for the fast and sensitive determination of chemical‐shift differences between overlapped resonances is proposed. The resulting fully homodecoupled 1 H NMR resonances appear as resolved 1D singlets without their typical J (HH) coupling constant multiplet structures. The high signal dispersion that is achieved is then exploited in enantiodiscrimination studies by using chiral solvating agents.