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Ultrafast Two‐Dimensional NMR Relaxometry for Investigating Molecular Processes in Real Time
Author(s) -
Ahola Susanna,
Telkki VilleVeikko
Publication year - 2014
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201301117
Subject(s) - relaxometry , relaxation (psychology) , two dimensional nuclear magnetic resonance spectroscopy , diffusion , spin–lattice relaxation , chemistry , temporal resolution , nuclear magnetic resonance , chemical physics , analytical chemistry (journal) , spin echo , physics , thermodynamics , optics , chromatography , medicine , nuclear quadrupole resonance , magnetic resonance imaging , radiology , psychology , social psychology
Nuclear spin–lattice ( T 1 ) and spin–spin ( T 2 ) relaxation times provide versatile information about the dynamics and structure of substances, such as proteins, polymers, porous media, and so forth. Multidimensional experiments increase the information content and resolution of NMR relaxometry, but they also multiply the measurement time. To overcome this issue, we present an efficient strategy for a single‐scan measurement of a 2D T 1 – T 2 correlation map. The method shortens the experimental time by one to three orders of magnitude as compared to the conventional method, offering an unprecedented opportunity to study molecular processes in real‐time. We demonstrate that, despite the tremendous speed‐up, the T 1 – T 2 correlation maps determined by the single‐scan method are in good agreement with the maps measured by the conventional method. The concept of the single‐scan T 1 – T 2 correlation experiment is applicable to a broad range of other multidimensional relaxation and diffusion experiments.