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Label‐Free Biosensing over a Wide Concentration Range with Photonic Force Microscopy
Author(s) -
Heo Seungjin,
Kim Kipom,
Cho YongHoon
Publication year - 2014
Publication title -
chemphyschem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.016
H-Index - 140
eISSN - 1439-7641
pISSN - 1439-4235
DOI - 10.1002/cphc.201301107
Subject(s) - biomolecule , biosensor , substrate (aquarium) , nanotechnology , microscopy , atomic force microscopy , materials science , chemistry , optics , physics , oceanography , geology
We present a label‐free biosensor that measures molecular interactions between biomolecules on the surface of a probe bead and substrate over a wide concentration range. This system is capable of detecting target biomolecules with concentrations varying from 10 n M to 0.1 p M , with high selectivity and sensitivity.